Cutaneous Squamous Cell Carcinoma

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:cancer
Skin Cancer
gptkbp:affects gptkb:skin
gptkbp:canMetastasizeTo Lymph nodes
Distant organs
gptkbp:complication Recurrence
Metastasis
Local tissue destruction
gptkbp:diagnosedBy Skin biopsy
gptkbp:firstDescribed 19th century
gptkbp:hasEpidemiology More common in men
More common in elderly
Second most common skin cancer
gptkbp:histology Atypical squamous cells
Invasion of dermis
Keratin pearls
https://www.w3.org/2000/01/rdf-schema#label Cutaneous Squamous Cell Carcinoma
gptkbp:ICD-10_code C44.2
gptkbp:location Hands
Arms
Ears
Face
gptkbp:MeSH_ID D018285
gptkbp:originatedIn Keratinocytes
gptkbp:prevention Sun protection
Avoidance of tanning beds
Regular skin checks
gptkbp:prognosis Generally good if detected early
Worse with metastasis
gptkbp:riskFactor gptkb:Human_papillomavirus_infection
Immunosuppression
Male sex
Older age
Fair skin
Chronic wounds
Chronic sun exposure
Ultraviolet radiation exposure
gptkbp:symptom Non-healing ulcer
Bleeding lesion
Firm nodule
Scaly red patch
gptkbp:synonym gptkb:cSCC
gptkb:cutaneous_SCC
gptkbp:treatment gptkb:Mohs_micrographic_surgery
radiation therapy
immunotherapy
Surgical excision
Cryotherapy
Topical chemotherapy
gptkbp:UMLS_CUI C0346629
gptkbp:bfsParent gptkb:cancer
gptkbp:bfsLayer 4