Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:cytochrome_bc1_complex
ubiquinol-cytochrome c reductase |
| gptkbp:cofactor |
gptkb:heme_b
2Fe-2S cluster heme c1 |
| gptkbp:component |
electron transport chain
|
| gptkbp:determines |
X-ray crystallography
|
| gptkbp:discoveredBy |
gptkb:David_E._Green
|
| gptkbp:discoveredIn |
1950s
|
| gptkbp:EC_number |
1.10.2.2
|
| gptkbp:foundIn |
eukaryotes
some bacteria |
| gptkbp:function |
pumps protons across mitochondrial membrane
transfers electrons from ubiquinol to cytochrome c |
| gptkbp:geneEncodingSubunit |
gptkb:MT-CYB
CYC1 UQCRC1 UQCRC2 UQCRFS1 UQCR UQCR10 UQCR11 UQCRB UQCRH UQCRQ |
| https://www.w3.org/2000/01/rdf-schema#label |
Complex III
|
| gptkbp:inhibitedBy |
gptkb:antimycin_A
myxothiazol stigmatellin |
| gptkbp:involvedIn |
ATP synthesis
|
| gptkbp:locatedIn |
inner mitochondrial membrane
|
| gptkbp:molecularWeight |
~250 kDa
|
| gptkbp:mutationAssociatedWith |
mitochondrial diseases
|
| gptkbp:numberOfSubunits |
11
|
| gptkbp:partOf |
oxidative phosphorylation
|
| gptkbp:PDB |
1BGY
1BCC 3CX5 |
| gptkbp:reactionCatalyzed |
QH2 + 2 ferricytochrome c + 2 H+ (matrix) → Q + 2 ferrocytochrome c + 4 H+ (intermembrane space)
|
| gptkbp:requires |
cellular respiration
|
| gptkbp:significance |
mutations linked to exercise intolerance
mutations linked to mitochondrial myopathy target for antimalarial drugs |
| gptkbp:subunit |
gptkb:cytochrome_b
gptkb:Rieske_iron-sulfur_protein gptkb:cytochrome_c1 |
| gptkbp:bfsParent |
gptkb:ubiquinol-cytochrome_c_reductase_complex
gptkb:Electron_Transport_Chain |
| gptkbp:bfsLayer |
8
|