Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Family C GPCRs
|
| gptkbp:associatedWith |
neurological disorders
metabolic disorders psychiatric disorders taste disorders |
| gptkbp:contains |
metabotropic glutamate receptors
GABA_B receptors orphan receptors calcium-sensing receptors taste receptors type 1 (TAS1R) |
| gptkbp:discoveredBy |
pharmacological studies
|
| gptkbp:domain |
cysteine-rich domain
Venus flytrap domain 7TM domain |
| gptkbp:evolvesFrom |
early metazoans
|
| gptkbp:foundIn |
invertebrates
vertebrates |
| gptkbp:function |
signal transduction
neurotransmitter binding |
| https://www.w3.org/2000/01/rdf-schema#label |
Class C GPCRs
|
| gptkbp:ligand |
ions
amino acids small molecules |
| gptkbp:locale |
gptkb:cell_membrane
taste buds neuronal synapses |
| gptkbp:OMIM |
601116
|
| gptkbp:pathway |
G protein signaling
second messenger pathways |
| gptkbp:proteinFamily |
CASR (calcium-sensing receptor gene)
GABBR (GABA_B receptor genes) GPCR, family C GRM (metabotropic glutamate receptor genes) TAS1R (taste receptor genes) |
| gptkbp:regulates |
dimerization
phosphorylation allosteric modulation |
| gptkbp:researchArea |
gptkb:pharmacy
molecular biology neuroscience |
| gptkbp:structure |
seven transmembrane helices
large extracellular N-terminal domain |
| gptkbp:subclassOf |
gptkb:G_protein-coupled_receptors
|
| gptkbp:targetOfDrug |
antipsychotics
antidepressants anxiolytics analgesics |
| gptkbp:bfsParent |
gptkb:G_protein-coupled_receptors_(Class_IB)
|
| gptkbp:bfsLayer |
6
|