|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:CS
gptkb:citrate_oxaloacetate-lyase
|
|
gptkbp:catalyzes
|
condensation of acetyl-CoA and oxaloacetate to form citrate
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:discoveredBy
|
gptkb:Hans_Adolf_Krebs
|
|
gptkbp:EC_number
|
2.3.3.1
|
|
gptkbp:foundIn
|
mitochondria
|
|
gptkbp:gene
|
gptkb:CS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Citrate synthase
|
|
gptkbp:involves
|
citric acid cycle
|
|
gptkbp:locale
|
mitochondrial matrix
|
|
gptkbp:molecularWeight
|
~50 kDa per subunit
|
|
gptkbp:notableAbsence
|
archaea (some species)
|
|
gptkbp:pathway
|
tricarboxylic acid cycle
|
|
gptkbp:PDB
|
gptkb:1CTS
|
|
gptkbp:presentIn
|
gptkb:Bacteria
eukaryotes
|
|
gptkbp:product
|
gptkb:CoA-SH
citrate
|
|
gptkbp:regulates
|
inhibited by ATP
inhibited by NADH
inhibited by citrate
inhibited by succinyl-CoA
|
|
gptkbp:requires
|
aerobic respiration
|
|
gptkbp:structure
|
homodimer in mammals
|
|
gptkbp:substrate
|
gptkb:oxaloacetate
acetyl-CoA
|
|
gptkbp:systematicName
|
gptkb:citrate_oxaloacetate-lyase_(CoA-acetylating)
|
|
gptkbp:type
|
aldol condensation
|
|
gptkbp:UniProtID
|
gptkb:O75390_(human)
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|