Cholangiocarcinoma

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:cancer
gptkb:disease
gptkbp:affects Bile ducts
gptkbp:alsoKnownAs Bile duct cancer
gptkbp:canMetastasizeTo gptkb:Peritoneum
Liver
Lung
Lymph nodes
gptkbp:complication Metastasis
Liver failure
Biliary obstruction
Cholangitis
gptkbp:diagnosedBy Imaging
Biopsy
Blood tests
gptkbp:firstDescribed 1840
gptkbp:hasBiomarker gptkb:KRAS_mutation
IDH1 mutation
ARID1A mutation
BAP1 mutation
FGFR2 fusion
gptkbp:hasEpidemiology Incidence increases with age
Slight male predominance
More common in Southeast Asia
gptkbp:hasTreatmentOption Palliative care
Liver transplantation
https://www.w3.org/2000/01/rdf-schema#label Cholangiocarcinoma
gptkbp:ICD-10_code C22.1
gptkbp:incidence Rare
gptkbp:originatedIn Epithelial cells of bile ducts
gptkbp:prognosis Poor
gptkbp:riskFactor gptkb:Hepatitis_B
gptkb:Hepatitis_C
Cirrhosis
Primary sclerosing cholangitis
Chronic biliary inflammation
Liver fluke infection
gptkbp:subspecies Distal cholangiocarcinoma
Intrahepatic cholangiocarcinoma
Perihilar cholangiocarcinoma
gptkbp:symptom Fever
Weight loss
Jaundice
Abdominal pain
gptkbp:treatment radiation therapy
Surgery
Chemotherapy
Targeted therapy
gptkbp:bfsParent gptkb:D008582
gptkbp:bfsLayer 6