|
gptkbp:instanceOf
|
neurodegenerative disease
|
|
gptkbp:affects
|
central nervous system
motor neurons
voluntary muscles
|
|
gptkbp:alsoKnownAs
|
gptkb:Amyotrophic_lateral_sclerosis
gptkb:Lou_Gehrig's_disease
|
|
gptkbp:averageSurvivalAfterDiagnosis
|
2-5 years
|
|
gptkbp:casualties
|
yes
|
|
gptkbp:category
|
motor neuron disease
|
|
gptkbp:cause
|
unknown
|
|
gptkbp:complication
|
gptkb:pneumonia
malnutrition
respiratory failure
|
|
gptkbp:diagnosedBy
|
MRI
clinical examination
electromyography
nerve conduction studies
|
|
gptkbp:differentialDiagnosis
|
gptkb:myasthenia_gravis
multiple sclerosis
spinal muscular atrophy
primary lateral sclerosis
progressive muscular atrophy
|
|
gptkbp:firstDescribed
|
gptkb:Jean-Martin_Charcot
1869
|
|
gptkbp:gender
|
more common in men
|
|
gptkbp:hasGeneticCause
|
C9orf72 mutation
FUS mutation
SOD1 mutation
TARDBP mutation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Charcot disease (ALS)
|
|
gptkbp:ICD-10_code
|
G12.2
|
|
gptkbp:incidence
|
1-2 per 100,000 per year
|
|
gptkbp:inheritance
|
familial
sporadic
|
|
gptkbp:namedAfter
|
gptkb:Jean-Martin_Charcot
|
|
gptkbp:notablePatient
|
gptkb:Stephen_Hawking
gptkb:Lou_Gehrig
|
|
gptkbp:onset
|
adulthood
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:prognosis
|
poor
|
|
gptkbp:progression
|
progressive
|
|
gptkbp:riskFactor
|
family history
genetic mutations
|
|
gptkbp:symptom
|
difficulty breathing
difficulty speaking
difficulty swallowing
muscle atrophy
muscle weakness
|
|
gptkbp:treatment
|
gptkb:edaravone
gptkb:riluzole
supportive care
|
|
gptkbp:bfsParent
|
gptkb:Jean-Martin_Charcot
|
|
gptkbp:bfsLayer
|
5
|