|
gptkbp:instanceOf
|
gptkb:drug
antihistamine
|
|
gptkbp:approvalYear
|
1995
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:R06AE07
|
|
gptkbp:availableOn
|
gptkb:sugar
gptkb:tablet
capsule
chewable tablet
oral solution
|
|
gptkbp:brand
|
gptkb:Zyrtec
gptkb:Aller-Tec
gptkb:Alleroff
gptkb:Cetirizine_Hydrochloride
gptkb:Reactine
Cetzine
|
|
gptkbp:CASNumber
|
83881-52-1
|
|
gptkbp:chemicalFormula
|
C21H25ClN2O3
|
|
gptkbp:contraindication
|
severe renal impairment
hypersensitivity to cetirizine
|
|
gptkbp:developedBy
|
gptkb:UCB
|
|
gptkbp:eliminationHalfLife
|
8.3 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:generation
|
second-generation antihistamine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cetirizine
|
|
gptkbp:legalStatus
|
OTC (over-the-counter)
|
|
gptkbp:mechanismOfAction
|
H1 receptor antagonist
|
|
gptkbp:metabolism
|
minimal
|
|
gptkbp:molecularWeight
|
388.888 g/mol
|
|
gptkbp:notableFor
|
low sedative effects
|
|
gptkbp:predecessor
|
hydroxyzine
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:prescriptionStatus
|
over-the-counter in many countries
prescription-only in some countries
|
|
gptkbp:proteinBinding
|
93%
|
|
gptkbp:PubChem_CID
|
gptkb:DB00341
2678
CHEMBL537
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
abdominal pain
dizziness
fatigue
headache
drowsiness
dry mouth
pharyngitis
|
|
gptkbp:UNII
|
YO7261ME24
|
|
gptkbp:usedFor
|
gptkb:hay_fever
allergic rhinitis
urticaria
allergy symptoms
|
|
gptkbp:bfsParent
|
gptkb:Antihistamines_for_systemic_use
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|