|
gptkbp:instanceOf
|
gptkb:CRISPR-Cas_system
|
|
gptkbp:alternativeName
|
gptkb:RfxCas13d
|
|
gptkbp:application
|
functional genomics
gene regulation
therapeutic development
|
|
gptkbp:discoveredBy
|
gptkb:Feng_Zhang
gptkb:Jonathan_S._Gootenberg
gptkb:Omar_O._Abudayyeh
|
|
gptkbp:discoveredIn
|
2018
|
|
gptkbp:doesNotTarget
|
gptkb:gene
|
|
gptkbp:engineeredFor
|
RNA base editing
splicing modulation
|
|
gptkbp:familyMember
|
gptkb:Cas13_family
|
|
gptkbp:function
|
RNA editing
RNA knockdown
|
|
gptkbp:hasCollateralActivity
|
no
|
|
gptkbp:hasGuideRNA
|
gptkb:crRNA
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CasRx
|
|
gptkbp:molecularWeight
|
112 kDa
|
|
gptkbp:notablePublication
|
gptkb:Konermann_et_al.,_Cell,_2018
Abudayyeh et al., Nature, 2017
|
|
gptkbp:originatedIn
|
gptkb:Ruminococcus_flavefaciens_XPD3002
|
|
gptkbp:relatedTo
|
gptkb:CRISPR-Cas13_system
CRISPR technology
|
|
gptkbp:target
|
single-stranded RNA
|
|
gptkbp:usedFor
|
high-throughput screening
RNA interference alternative
|
|
gptkbp:usedIn
|
mammalian cells
in vivo studies
|
|
gptkbp:bfsParent
|
gptkb:Cas13d
|
|
gptkbp:bfsLayer
|
7
|