|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:CAIX
Carbonate dehydratase IX
MN antigen
|
|
gptkbp:associatedWith
|
tumor hypoxia
|
|
gptkbp:EC_number
|
4.2.1.1
|
|
gptkbp:encodedBy
|
CA9 gene
|
|
gptkbp:expressed_in_response_to
|
gptkb:hypoxia
|
|
gptkbp:expressedIn
|
gastrointestinal tract
tumor cells
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
catalyzes reversible hydration of carbon dioxide
|
|
gptkbp:gene
|
CA9
|
|
gptkbp:HGNC_ID
|
1374
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Carbonic anhydrase IX
|
|
gptkbp:involves
|
cell proliferation
pH regulation
|
|
gptkbp:locatedOnChromosome
|
9p13.3
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~54 kDa
|
|
gptkbp:OMIM
|
601762
|
|
gptkbp:overexpressedIn
|
renal cell carcinoma
|
|
gptkbp:regulates
|
gptkb:HIF-1α
|
|
gptkbp:structure
|
contains a catalytic domain
contains a proteoglycan-like domain
contains a transmembrane domain
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
Q16790
|
|
gptkbp:usedFor
|
tumor biomarker
|
|
gptkbp:bfsParent
|
gptkb:CHEMBL1201737
|
|
gptkbp:bfsLayer
|
7
|