CRISPR-associated protein 9 (Cas9)
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
endonuclease |
| gptkbp:discoveredBy |
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna |
| gptkbp:discoveredIn |
2012
|
| gptkbp:domain |
gptkb:HNH
gptkb:REC gptkb:RuvC PI |
| gptkbp:foundIn |
gptkb:Streptococcus_pyogenes
|
| gptkbp:function |
genome editing
DNA cleavage |
| gptkbp:gene |
cas9
|
| https://www.w3.org/2000/01/rdf-schema#label |
CRISPR-associated protein 9 (Cas9)
|
| gptkbp:molecularWeight |
~160 kDa
|
| gptkbp:PAM_sequence |
gptkb:NGG
|
| gptkbp:partOf |
CRISPR adaptive immune system
|
| gptkbp:recognizedBy |
PAM sequence
|
| gptkbp:requires |
gptkb:guide_RNA
|
| gptkbp:structure |
bilobed
|
| gptkbp:usedFor |
gptkb:gene_drive
gptkb:agricultural_machinery biomedical research cancer research personalized medicine synthetic biology vaccine development diagnostics immunotherapy base editing prime editing disease modeling functional genomics crop improvement epigenome editing gene activation gene repression bioproduction microbial engineering bioremediation gene therapy research antibiotic resistance studies animal model generation antiviral research live-cell imaging genetic screens transgenic organism creation |
| gptkbp:usedIn |
gene editing
genome engineering gene knockout |
| gptkbp:bfsParent |
gptkb:CRISPR-Cas9_gene_editing_technology
|
| gptkbp:bfsLayer |
5
|