CRISPR-associated protein 9 (Cas9)
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:endonuclease |
| gptkbp:discoveredBy |
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna |
| gptkbp:discoveredIn |
2012
|
| gptkbp:domain |
gptkb:HNH
gptkb:REC gptkb:RuvC PI |
| gptkbp:foundIn |
gptkb:Streptococcus_pyogenes
|
| gptkbp:function |
genome editing
DNA cleavage |
| gptkbp:gene |
cas9
|
| gptkbp:molecularWeight |
~160 kDa
|
| gptkbp:PAM_sequence |
gptkb:NGG
|
| gptkbp:partOf |
CRISPR adaptive immune system
|
| gptkbp:recognizedBy |
PAM sequence
|
| gptkbp:requires |
gptkb:guide_RNA
|
| gptkbp:structure |
bilobed
|
| gptkbp:usedFor |
gptkb:immunotherapy
gptkb:gene_drive gptkb:agricultural_machinery biomedical research cancer research personalized medicine synthetic biology vaccine development diagnostics base editing prime editing disease modeling functional genomics crop improvement epigenome editing gene activation gene repression bioproduction microbial engineering bioremediation gene therapy research antibiotic resistance studies animal model generation antiviral research live-cell imaging genetic screens transgenic organism creation |
| gptkbp:usedIn |
gene editing
genome engineering gene knockout |
| gptkbp:bfsParent |
gptkb:CRISPR-Cas9_gene_editing_technology
|
| gptkbp:bfsLayer |
6
|
| https://www.w3.org/2000/01/rdf-schema#label |
CRISPR-associated protein 9 (Cas9)
|