CRISPR-associated protein 9 (Cas9)
GPTKB entity
Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
agriculture
biomedical research therapeutics |
| gptkbp:associated_with |
gptkb:biotechnology
|
| gptkbp:business_model |
gene editing ethics
|
| gptkbp:co-factors |
gptkb:tracr_RNA
|
| gptkbp:collaborates_with |
other proteins
|
| gptkbp:collaboration |
international research collaborations
|
| gptkbp:developed_by |
gptkb:Streptococcus_pyogenes
|
| gptkbp:discovered_by |
gptkb:2012
|
| gptkbp:forms_complex_with |
sg RNA
|
| gptkbp:function |
gene editing
|
| gptkbp:future_plans |
biomedical applications
gene therapy advancements agricultural innovations |
| gptkbp:future_prospects |
gptkb:cancer_treatment
genetic disorders treatment infectious diseases treatment |
| gptkbp:has_limitations |
off-target effects
delivery challenges |
| https://www.w3.org/2000/01/rdf-schema#label |
CRISPR-associated protein 9 (Cas9)
|
| gptkbp:impact |
reduced pesticide use
promoted sustainable agriculture revolutionized genetic engineering accelerated research in genetics developed disease-resistant plants enabled precise modifications enhanced agricultural biotechnology facilitated synthetic biology improved crop traits increased yield in crops |
| gptkbp:initiated_by |
gene expression
|
| gptkbp:invention |
numerous patents filed
|
| gptkbp:involved_in |
adaptive immunity
transcriptional regulation |
| gptkbp:mechanism_of_action |
RNA-guided DNA endonuclease
|
| gptkbp:origin |
gptkb:Biology
|
| gptkbp:promotes |
DNA repair
|
| gptkbp:requires |
guide RNA
|
| gptkbp:research_areas |
gptkb:biotechnology
gptkb:Genetics molecular biology |
| gptkbp:research_institutes |
pharmaceutical companies
biotech companies widely studied in universities |
| gptkbp:size |
approximately 160 k Da
|
| gptkbp:targets |
specific DNA sequences
double-stranded DNA |
| gptkbp:used_for |
gene replacement
gene insertion knockout of genes |
| gptkbp:used_in |
clinical trials
genome engineering |