COMP protein

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:thrombospondin-5
gptkbp:associatedWith gptkb:pseudoachondroplasia
gptkb:multiple_epiphyseal_dysplasia
osteoarthritis
gptkbp:discoveredBy HeinegÄrd D et al.
gptkbp:discoveredIn 1992
gptkbp:encodedBy gptkb:COMP_gene
gptkbp:foundIn gptkb:skin
collagen
tendon
vascular smooth muscle
ligament
synovium
gptkbp:fullName Cartilage Oligomeric Matrix Protein
gptkbp:function structural component of extracellular matrix
interacts with collagen
involved in cartilage development
involved in tissue repair
gptkbp:gene gptkb:COMP
https://www.w3.org/2000/01/rdf-schema#label COMP protein
gptkbp:locatedOnChromosome gptkb:19p13.1
gptkbp:memberOf thrombospondin family
gptkbp:molecularWeight ~524 kDa (pentamer)
gptkbp:OMIM 600310
gptkbp:PDB 3FBY
gptkbp:postTranslationalModification glycosylation
disulfide bond formation
gptkbp:structure pentameric glycoprotein
gptkbp:UniProtID P49747
gptkbp:usedAs biomarker for joint disease
gptkbp:bfsParent gptkb:COMP_gene
gptkbp:bfsLayer 8