|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CMS
gptkb:CD2-associated_protein
KIAA0469
|
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
Focal segmental glomerulosclerosis
|
|
gptkbp:biologicalProcess
|
cell adhesion
endocytosis
actin cytoskeleton organization
|
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gptkbp:cellularComponent
|
gptkb:cell_junction
gptkb:cytoplasm
|
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gptkbp:domain
|
SH3 domain
coiled-coil domain
|
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gptkbp:Entrez_Gene_ID
|
23607
ENSG00000198087
|
|
gptkbp:expressedIn
|
gptkb:kidney
immune cells
|
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gptkbp:externalLink
|
https://www.uniprot.org/uniprot/Q9Y5K6
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gptkbp:function
|
involved in endocytosis
adaptor protein involved in cytoskeletal organization
regulates actin cytoskeleton
involved in podocyte function
|
|
gptkbp:gene
|
gptkb:CD2AP
|
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gptkbp:goMolecularFunction
|
protein binding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD2AP HUMAN
|
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gptkbp:interactsWith
|
gptkb:SH3KBP1
gptkb:Nephrin
FYN
CD2
CIN85
|
|
gptkbp:length
|
639 amino acids
|
|
gptkbp:locatedOnChromosome
|
6
|
|
gptkbp:location
|
6p12.3
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:mutationAssociatedWith
|
causes nephrotic syndrome in mice
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Cd2ap (mouse)
cd2ap (zebrafish)
|
|
gptkbp:pathway
|
endocytosis pathway
actin cytoskeleton regulation
|
|
gptkbp:PDB
|
2RPN
|
|
gptkbp:phosphorylates
|
Serine 458
Tyrosine 461
|
|
gptkbp:RefSeq
|
NP_036266.2
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
cytoskeleton
|
|
gptkbp:UniProtID
|
Q9Y5K6
|
|
gptkbp:bfsParent
|
gptkb:CD2AP
|
|
gptkbp:bfsLayer
|
8
|