Buchwald–Hartwig amination

GPTKB entity

Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:application material science
pharmaceutical synthesis
gptkbp:basisFor potassium tert-butoxide
sodium tert-butoxide
gptkbp:catalyzes nickel
palladium
gptkbp:field organic chemistry
gptkbp:firstReported 1994
https://www.w3.org/2000/01/rdf-schema#label Buchwald–Hartwig amination
gptkbp:importantFor widely used in organic synthesis
gptkbp:ligand phosphine ligand
gptkbp:mechanismOfAction palladium-catalyzed
gptkbp:namedAfter gptkb:John_F._Hartwig
gptkb:Stephen_L._Buchwald
gptkbp:product aryl amine
gptkbp:reactant amphetamine
aryl halide
gptkbp:relatedTo gptkb:Ullmann_reaction
gptkb:Suzuki_coupling
gptkbp:solvent toluene
dioxane
gptkbp:step oxidative addition
reductive elimination
amine coordination
gptkbp:type cross-coupling reaction
gptkbp:bfsParent gptkb:Stephen_Buchwald
gptkb:John_F._Hartwig
gptkb:Stephen_L._Buchwald
gptkbp:bfsLayer 6