BRAF V600 K mutation-positive melanoma
GPTKB entity
Statements (92)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:healthcare_organization
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:Trametinib
|
| gptkbp:belligerent |
advanced stages
BRAF wild-type melanoma |
| gptkbp:can_lead_to |
metastasis
|
| gptkbp:caused_by |
skin lesions
|
| gptkbp:disease_resistance |
targeted therapy
|
| gptkbp:exhibits |
itching
|
| gptkbp:genetic_diversity |
BRAF V600 K
|
| gptkbp:hosts |
gptkb:vaccine
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRAF V600 K mutation-positive melanoma
|
| gptkbp:is_affected_by |
environmental factors
treatment adherence age |
| gptkbp:is_analyzed_in |
clinical research
epidemiological studies pathology genomic studies genetic counseling |
| gptkbp:is_associated_with |
targeted therapy
tumor heterogeneity tumor microenvironment specific biomarkers poor prognosis tumor markers increased risk of recurrence increased tumor growth |
| gptkbp:is_characterized_by |
abnormal cell growth
abnormal BRAF protein |
| gptkbp:is_considered |
treatment guidelines
a public health concern a significant health issue a complex disease aggressive cancer a serious health condition a subtype of melanoma |
| gptkbp:is_considered_as |
target for therapy
|
| gptkbp:is_discussed_in |
gptkb:academic_journal
|
| gptkbp:is_evaluated_by |
imaging studies
clinical settings clinical assessments therapeutic studies |
| gptkbp:is_influenced_by |
lifestyle choices
|
| gptkbp:is_linked_to |
immune response
family history sun exposure genetic predisposition treatment outcomes poor prognosis increased mutation burden increased risk of recurrence |
| gptkbp:is_monitored_by |
follow-up care
|
| gptkbp:is_often_depicted_as |
skin lesions
|
| gptkbp:is_often_used_in |
Caucasians
younger adults advanced melanoma |
| gptkbp:is_part_of |
cancer research
precision medicine cancer genomics melanoma research melanoma classification melanoma treatment guidelines |
| gptkbp:is_recognized_by |
genetic testing
|
| gptkbp:is_related_to |
BRAF gene
|
| gptkbp:is_studied_in |
clinical trials
laboratory research pharmacogenomics |
| gptkbp:is_subject_to |
monitoring
ongoing research |
| gptkbp:is_tested_for |
genetic testing
|
| gptkbp:is_used_for |
resistance to treatment
|
| gptkbp:managed_by |
patient education
supportive care oncologists multidisciplinary care |
| gptkbp:occurs_in |
gptkb:skincare_product
adults |
| gptkbp:recognizes |
biopsy
|
| gptkbp:screenings |
early detection
|
| gptkbp:social_responsibility |
biopsy
dermatoscopy |
| gptkbp:treatment |
gptkb:dabrafenib
gptkb:hospital gptkb:vaccine combination therapy targeted therapies radiation therapy chemotherapy BRAF inhibitors novel therapies adjuvant therapy |