|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:administeredBy
|
oral
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
|
gptkbp:ATCCode
|
L01EB03
|
|
gptkbp:brand
|
gptkb:Gilotrif
gptkb:Giotrif
|
|
gptkbp:CASNumber
|
439081-18-2
|
|
gptkbp:developedBy
|
gptkb:Boehringer_Ingelheim
|
|
gptkbp:eliminatedIn
|
urine
feces
|
|
gptkbp:halfLife
|
37 hours
|
|
gptkbp:hasInChIKey
|
gptkb:WWUZIQQURGPMPG-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C24H25ClFN5O3
|
|
gptkbp:hasSMILES
|
CN(C)CC C(=O)Nc1ccc2c(c1)nc(nc2Oc3cc(ccc3)Cl)Nc4ccc(cc4)F
|
|
gptkbp:IUPACName
|
(2E)-N-{4-(3-chloro-4-fluoroanilino)-7-[(3S)-tetrahydrofuran-3-yl]oxyquinazolin-6-yl}-4-(dimethylamino)but-2-enamide
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
gptkb:EGFR_inhibitor
HER2 inhibitor
|
|
gptkbp:molecularWeight
|
485.94 g/mol
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
fatigue
pruritus
rash
dry skin
decreased appetite
stomatitis
paronychia
|
|
gptkbp:synonym
|
gptkb:afatinib
|
|
gptkbp:target
|
gptkb:EGFR
gptkb:ErbB_family
HER2
|
|
gptkbp:usedFor
|
gptkb:non-small_cell_lung_cancer
|
|
gptkbp:bfsParent
|
gptkb:Afatinib
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BIBW 2992
|