Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
neurodegenerative disease
|
| gptkbp:affects |
brain
|
| gptkbp:alsoKnownAs |
gptkb:AD
gptkb:Alzheimer's_disease |
| gptkbp:associatedWith |
gptkb:Down_syndrome
vascular dementia Lewy body dementia |
| gptkbp:averageSpeed |
8-10 years after diagnosis
|
| gptkbp:characterizedBy |
behavioral changes
cognitive decline progressive memory loss |
| gptkbp:diagnosedBy |
brain imaging
clinical assessment neuropsychological tests biomarker tests |
| gptkbp:firstDescribed |
gptkb:Alois_Alzheimer
1906 |
| gptkbp:hasNoCure |
true
|
| https://www.w3.org/2000/01/rdf-schema#label |
Alzheimer Disease
|
| gptkbp:ICD-10_code |
gptkb:G30
|
| gptkbp:MeSH_ID |
gptkb:D000544
|
| gptkbp:mostCommonCauseOf |
gptkb:dementia
|
| gptkbp:namedAfter |
gptkb:Alois_Alzheimer
|
| gptkbp:OMIM |
104300
|
| gptkbp:pathology |
amyloid plaques
neurofibrillary tangles neuronal loss |
| gptkbp:prevalence |
millions affected worldwide
most common in people over 65 |
| gptkbp:prognosis |
progressive and fatal
|
| gptkbp:researchInterest |
disease-modifying therapies
early detection genetic risk factors |
| gptkbp:riskFactor |
gptkb:APOE-e4_allele
gptkb:cardiovascular_disease age family history genetic factors head injury |
| gptkbp:symptom |
behavioral issues
confusion difficulty with language disorientation loss of motivation memory loss mood swings self-neglect |
| gptkbp:treatment |
gptkb:memantine
acetylcholinesterase inhibitors behavioral therapy supportive care |
| gptkbp:bfsParent |
gptkb:NCT05240898
|
| gptkbp:bfsLayer |
7
|