|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:A1AT
gptkb:alpha1-proteinase_inhibitor
|
|
gptkbp:category
|
acute phase protein
serpin family
|
|
gptkbp:deficiencyCauses
|
gptkb:liver_disease
emphysema
|
|
gptkbp:discoveredBy
|
Laurell and Eriksson
|
|
gptkbp:discoveredIn
|
1963
|
|
gptkbp:encodedBy
|
gptkb:SERPINA1_gene
|
|
gptkbp:foundIn
|
blood plasma
|
|
gptkbp:function
|
gptkb:serine_protease
|
|
gptkbp:halfLife
|
4–5 days
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Alpha-1 antitrypsin
|
|
gptkbp:inhibitedBy
|
neutrophil elastase
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q32.13
|
|
gptkbp:medicalUse
|
diagnosis of deficiency
|
|
gptkbp:molecularWeight
|
52 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Z_allele
S allele
|
|
gptkbp:normalSerumLevel
|
1.5–3.5 g/L
|
|
gptkbp:OMIM
|
107400
|
|
gptkbp:presentIn
|
extracellular space
lung tissue
|
|
gptkbp:producedBy
|
liver
|
|
gptkbp:role
|
inflammation regulation
protection of lung tissue
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:treatment
|
augmentation therapy
|
|
gptkbp:UniProtID
|
P01009
|
|
gptkbp:bfsParent
|
gptkb:AAT
|
|
gptkbp:bfsLayer
|
7
|