|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
Asp33
Lys229
|
|
gptkbp:alternativeName
|
gptkb:fructose-bisphosphate_aldolase_A
|
|
gptkbp:associatedWith
|
gptkb:anemia
muscular dystrophy
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:discoveredBy
|
1940s
|
|
gptkbp:EC_number
|
4.1.2.13
|
|
gptkbp:encodedBy
|
ALDOA gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000149925
GC16M030774
|
|
gptkbp:enzymeClassification
|
lyase
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver (fetal)
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
erythrocytes
developing embryo
|
|
gptkbp:function
|
catalyzes the reversible cleavage of fructose 1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
|
|
gptkbp:gene
|
gptkb:ALDOA
|
|
gptkbp:HGNC_ID
|
405
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Aldolase A
|
|
gptkbp:inhibitedBy
|
citrate
phosphoenolpyruvate
oxalate
|
|
gptkbp:locatedOnChromosome
|
16q22.2
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:OMIM
|
103850
|
|
gptkbp:orthologInMouse
|
gptkb:Aldoa
|
|
gptkbp:orthologInZebrafish
|
aldoaa
|
|
gptkbp:pathway
|
glycolysis
gluconeogenesis
|
|
gptkbp:PDB
|
gptkb:4ALD
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:product
|
gptkb:glyceraldehyde_3-phosphate
dihydroxyacetone phosphate
|
|
gptkbp:proteinFamily
|
class I aldolase
|
|
gptkbp:significance
|
deficiency causes glycogen storage disease type XII
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:substrate
|
gptkb:fructose_1,6-bisphosphate
|
|
gptkbp:UniProtID
|
P04075
|
|
gptkbp:bfsParent
|
gptkb:Aldolase
|
|
gptkbp:bfsLayer
|
7
|