Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
|
| gptkbp:application |
targeted protein degradation
|
| gptkbp:canBe |
gptkb:cancer
therapeutics for neurodegenerative diseases |
| gptkbp:component |
autophagy-targeting ligand
target protein ligand |
| gptkbp:developedBy |
gptkb:Noboru_Mizushima
|
| gptkbp:effect |
promotes lysosomal degradation
|
| gptkbp:firstDescribed |
2019
|
| gptkbp:fullName |
Autophagy-targeting chimeras
|
| gptkbp:function |
induce autophagy-mediated degradation of target proteins
|
| https://www.w3.org/2000/01/rdf-schema#label |
AUTACs
|
| gptkbp:mechanismOfAction |
tag target proteins for selective autophagy
utilizes S-guanylation signal for autophagy |
| gptkbp:relatedTo |
gptkb:LYTACs
PROTACs |
| gptkbp:structure |
bifunctional molecule
|
| gptkbp:target |
damaged organelles
cytosolic proteins |
| gptkbp:usedIn |
biomedical research
|
| gptkbp:bfsParent |
gptkb:Targeted_Protein_Degradation
|
| gptkbp:bfsLayer |
8
|