LYTACs

GPTKB entity

Statements (21)
Predicate Object
gptkbp:instanceOf gptkb:biotechnology
protein degradation technology
gptkbp:application targeting disease-associated proteins
therapeutic protein degradation
gptkbp:canBe gptkb:cancer
autoimmune disease treatment
neurodegenerative disease treatment
gptkbp:developedBy gptkb:Carolyn_Bertozzi
gptkbp:distinctFrom PROTACs target intracellular proteins, LYTACs target extracellular/membrane proteins
gptkbp:firstDescribed 2020
gptkbp:fullName Lysosome-targeting chimeras
gptkbp:function target extracellular and membrane proteins for lysosomal degradation
https://www.w3.org/2000/01/rdf-schema#label LYTACs
gptkbp:mechanismOfAction bind target protein and lysosome-shuttling receptor
gptkbp:publishedIn gptkb:Nature
gptkbp:relatedTo PROTACs
gptkbp:species gptkb:human
gptkb:mouse
gptkbp:targetReceptor cation-independent mannose-6-phosphate receptor
gptkbp:bfsParent gptkb:Targeted_Protein_Degradation
gptkbp:bfsLayer 8