Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein_degradation_technology
gptkb:biotechnology |
| gptkbp:application |
targeting disease-associated proteins
therapeutic protein degradation |
| gptkbp:canBe |
gptkb:cancer
autoimmune disease treatment neurodegenerative disease treatment |
| gptkbp:developedBy |
gptkb:Carolyn_Bertozzi
|
| gptkbp:distinctFrom |
PROTACs target intracellular proteins, LYTACs target extracellular/membrane proteins
|
| gptkbp:firstDescribed |
2020
|
| gptkbp:fullName |
Lysosome-targeting chimeras
|
| gptkbp:function |
target extracellular and membrane proteins for lysosomal degradation
|
| gptkbp:mechanismOfAction |
bind target protein and lysosome-shuttling receptor
|
| gptkbp:publishedIn |
gptkb:Nature
|
| gptkbp:relatedTo |
PROTACs
|
| gptkbp:species |
gptkb:human
gptkb:mouse |
| gptkbp:targetReceptor |
cation-independent mannose-6-phosphate receptor
|
| gptkbp:bfsParent |
gptkb:Targeted_Protein_Degradation
|
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
LYTACs
|