Properties (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gene
|
| gptkbp:associatedWith |
DNA damage response
Fanconi anemia pathway |
| gptkbp:code |
gptkb:ATR_protein
|
| gptkbp:diedIn |
tumor suppression
telomere maintenance |
| gptkbp:diseaseResistance |
ataxia telangiectasia-like disorder
|
| gptkbp:established |
scientists in the late 1990s
|
| gptkbp:geneticDiversity |
increased cancer risk
several cancer types |
| gptkbp:hasHistory |
other species
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATR gene
|
| gptkbp:influences |
cellular response to UV radiation
|
| gptkbp:interactsWith |
gptkb:ATM_protein
BRCA1 protein |
| gptkbp:involvedIn |
cell cycle regulation
chromosomal stability response to replication stress |
| gptkbp:is_essential_for |
embryonic development
|
| gptkbp:is_evaluated_by |
various tissues
cancer cells |
| gptkbp:isActiveIn |
apoptosis under certain conditions
|
| gptkbp:isAssociatedWith |
age-related diseases
metabolic disorders chromosomal abnormalities |
| gptkbp:isInvolvedIn |
cellular homeostasis
immune response tumorigenesis tumor microenvironment cellular differentiation cellular signaling pathways genomic integrity stress response pathways |
| gptkbp:isLinkedTo |
neurodegenerative diseases
cellular aging developmental disorders therapeutic resistance |
| gptkbp:isLocatedIn |
stem cells
various cancers |
| gptkbp:isPartOf |
DNA damage checkpoint
DNA repair pathways cellular signaling networks cellular repair processes |
| gptkbp:isRegulatedBy |
p53 protein
cell cycle proteins |
| gptkbp:isStudiedIn |
therapeutic targets
|
| gptkbp:isUtilizedFor |
DNA replication
cellular response to DNA damage cellular survival |
| gptkbp:linkedTo |
genomic stability
|
| gptkbp:locatedIn |
human chromosome 3
|
| gptkbp:partOf |
DNA damage signaling pathway
|
| gptkbp:regulates |
DNA repair mechanisms
checkpoint kinase 1 (CHK1) |
| gptkbp:research |
cancer research
|