Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:associatedWith |
genome instability
HIV-1 restriction cancer hypermutation |
| gptkbp:cofactor |
zinc
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:enzyme |
cytidine deaminase activity
|
| gptkbp:foundIn |
humans
mammals |
| gptkbp:fullName |
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like enzymes
|
| gptkbp:function |
RNA editing
DNA editing cytidine deamination |
| https://www.w3.org/2000/01/rdf-schema#label |
APOBEC enzymes
|
| gptkbp:inhibitedBy |
HIV-1 Vif protein
|
| gptkbp:locatedOnChromosome |
chromosome 22 (APOBEC3 cluster in humans)
|
| gptkbp:mechanismOfAction |
deamination of cytosine to uracil
|
| gptkbp:memberOf |
cytidine deaminase superfamily
|
| gptkbp:mutationSignature |
C-to-G transversions
C-to-T transitions |
| gptkbp:notableMember |
gptkb:AID
APOBEC1 APOBEC2 APOBEC3 APOBEC4 |
| gptkbp:proteinFamily |
APOBEC gene family
|
| gptkbp:relatedTo |
APOBEC3G
AID (Activation-Induced cytidine Deaminase) APOBEC3A APOBEC3B APOBEC3C APOBEC3D APOBEC3E APOBEC3F APOBEC3H |
| gptkbp:role |
innate immunity
antiviral defense cancer mutagenesis mutation of host genomes mutation of viral genomes restriction of retroelements restriction of retroviruses |
| gptkbp:structure |
zinc-dependent deaminase domain
|
| gptkbp:studiedIn |
immunology
virology cancer genomics |
| gptkbp:substrate |
gptkb:gene
single-stranded DNA |
| gptkbp:bfsParent |
gptkb:Reuben_Harris
|
| gptkbp:bfsLayer |
8
|