Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
animal model
|
| gptkbp:developedBy |
1994
|
| gptkbp:firstModel |
gptkb:SOD1-G93A_mouse
|
| https://www.w3.org/2000/01/rdf-schema#label |
ALS mouse models
|
| gptkbp:include |
gptkb:C9orf72_mouse
gptkb:FUS_transgenic_mouse gptkb:SOD1-G93A_mouse gptkb:TDP-43_transgenic_mouse |
| gptkbp:limitation |
do not fully recapitulate human ALS
limited lifespan species differences variable disease onset variable disease progression |
| gptkbp:organism |
gptkb:Mus_musculus
|
| gptkbp:relatedTo |
gptkb:ALS_cell_models
gptkb:ALS_rat_models |
| gptkbp:usedBy |
pharmaceutical companies
ALS researchers academic laboratories |
| gptkbp:usedFor |
amyotrophic lateral sclerosis research
preclinical drug testing studying neuroinflammation studying protein aggregation studying disease progression studying genetic mutations in ALS studying motor neuron degeneration |
| gptkbp:bfsParent |
gptkb:mouse_SOD1
|
| gptkbp:bfsLayer |
6
|