Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:transgenic_mouse_model
gptkb:ALS_mouse_model |
| gptkbp:backgroundStrain |
gptkb:C57BL/6
B6SJL |
| gptkbp:citation |
Gurney ME et al., Science, 1994
|
| gptkbp:depot |
gptkb:The_Jackson_Laboratory
|
| gptkbp:diseaseModelOf |
amyotrophic lateral sclerosis
|
| gptkbp:expressedIn |
human SOD1 gene with G93A mutation
|
| gptkbp:firstDescribed |
1994
|
| gptkbp:hasPhenotype |
paralysis
muscle weakness reduced lifespan progressive motor neuron degeneration |
| gptkbp:inheritance |
autosomal dominant
|
| gptkbp:JAXStockNumber |
002726
|
| gptkbp:lifespan |
~120-140 days (high copy)
|
| gptkbp:motorNeuronLoss |
gptkb:spinal_cord
|
| gptkbp:mutationAminoAcidChange |
glycine to alanine at position 93
|
| gptkbp:mutationAssociatedWith |
missense mutation
G93A in SOD1 gene |
| gptkbp:origin |
created by Gurney et al. 1994
|
| gptkbp:sexDifference |
males and females affected similarly
|
| gptkbp:transgeneCopyNumber |
high copy
|
| gptkbp:usedFor |
amyotrophic lateral sclerosis research
preclinical drug testing studying mitochondrial dysfunction studying neurodegeneration studying oxidative stress studying protein aggregation studying glial cell involvement in ALS |
| gptkbp:bfsParent |
gptkb:ALS_mouse_models
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
SOD1-G93A mouse
|