Statements (34)
Predicate | Object |
---|---|
gptkbp:instanceOf |
ALS mouse model
transgenic mouse model |
gptkbp:backgroundStrain |
gptkb:C57BL/6
B6SJL |
gptkbp:citation |
Gurney ME et al., Science, 1994
|
gptkbp:depot |
gptkb:The_Jackson_Laboratory
|
gptkbp:diseaseModelOf |
amyotrophic lateral sclerosis
|
gptkbp:expressedIn |
human SOD1 gene with G93A mutation
|
gptkbp:firstDescribed |
1994
|
gptkbp:hasPhenotype |
paralysis
muscle weakness reduced lifespan progressive motor neuron degeneration |
https://www.w3.org/2000/01/rdf-schema#label |
SOD1-G93A mouse
|
gptkbp:inheritance |
autosomal dominant
|
gptkbp:JAXStockNumber |
002726
|
gptkbp:lifespan |
~120-140 days (high copy)
|
gptkbp:motorNeuronLoss |
gptkb:spinal_cord
|
gptkbp:mutationAminoAcidChange |
glycine to alanine at position 93
|
gptkbp:mutationAssociatedWith |
missense mutation
G93A in SOD1 gene |
gptkbp:origin |
created by Gurney et al. 1994
|
gptkbp:sexDifference |
males and females affected similarly
|
gptkbp:transgeneCopyNumber |
high copy
|
gptkbp:usedFor |
amyotrophic lateral sclerosis research
preclinical drug testing studying mitochondrial dysfunction studying neurodegeneration studying oxidative stress studying protein aggregation studying glial cell involvement in ALS |
gptkbp:bfsParent |
gptkb:ALS_mouse_models
gptkb:ALS_mouse_model |
gptkbp:bfsLayer |
7
|