SOD1-G93A mouse

GPTKB entity

Statements (34)
Predicate Object
gptkbp:instanceOf ALS mouse model
transgenic mouse model
gptkbp:backgroundStrain gptkb:C57BL/6
B6SJL
gptkbp:citation Gurney ME et al., Science, 1994
gptkbp:depot gptkb:The_Jackson_Laboratory
gptkbp:diseaseModelOf amyotrophic lateral sclerosis
gptkbp:expressedIn human SOD1 gene with G93A mutation
gptkbp:firstDescribed 1994
gptkbp:hasPhenotype paralysis
muscle weakness
reduced lifespan
progressive motor neuron degeneration
https://www.w3.org/2000/01/rdf-schema#label SOD1-G93A mouse
gptkbp:inheritance autosomal dominant
gptkbp:JAXStockNumber 002726
gptkbp:lifespan ~120-140 days (high copy)
gptkbp:motorNeuronLoss gptkb:spinal_cord
gptkbp:mutationAminoAcidChange glycine to alanine at position 93
gptkbp:mutationAssociatedWith missense mutation
G93A in SOD1 gene
gptkbp:origin created by Gurney et al. 1994
gptkbp:sexDifference males and females affected similarly
gptkbp:transgeneCopyNumber high copy
gptkbp:usedFor amyotrophic lateral sclerosis research
preclinical drug testing
studying mitochondrial dysfunction
studying neurodegeneration
studying oxidative stress
studying protein aggregation
studying glial cell involvement in ALS
gptkbp:bfsParent gptkb:ALS_mouse_models
gptkb:ALS_mouse_model
gptkbp:bfsLayer 7