Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
laboratory animal
transgenic mouse model |
| gptkbp:createdBy |
genetic engineering
|
| gptkbp:expressedIn |
human TDP-43 protein
|
| gptkbp:hasModel |
amyotrophic lateral sclerosis
frontotemporal lobar degeneration |
| https://www.w3.org/2000/01/rdf-schema#label |
TDP-43 transgenic mouse
|
| gptkbp:shows |
muscle atrophy
cognitive deficits motor neuron degeneration neuroinflammation TDP-43 proteinopathy progressive paralysis cytoplasmic TDP-43 inclusions loss of motor neurons spinal cord pathology |
| gptkbp:studiedBy |
neuroscientists
|
| gptkbp:usedFor |
ALS research
neurodegenerative disease research frontotemporal dementia research testing therapeutic interventions |
| gptkbp:bfsParent |
gptkb:ALS_mouse_models
gptkb:ALS_mouse_model |
| gptkbp:bfsLayer |
7
|