ALS (Lou Gehrig's disease)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease
gptkbp:affects	lower motor neurons motor neurons upper motor neurons
gptkbp:alsoKnownAs	gptkb:Amyotrophic_lateral_sclerosis gptkb:Lou_Gehrig's_disease
gptkbp:averageOnsetAge	55
gptkbp:awarenessEvent	gptkb:ALS_Ice_Bucket_Challenge
gptkbp:casualties	yes
gptkbp:category	motor neuron disease
gptkbp:cause	difficulty breathing difficulty speaking difficulty swallowing muscle atrophy muscle weakness
gptkbp:causedBy	C9orf72 gene mutation (in some cases) FUS gene mutation (in some cases) SOD1 gene mutation (in some cases) TARDBP gene mutation (in some cases)
gptkbp:compatibleWith	sensory nerves cognitive function (in most cases)
gptkbp:diagnosedBy	MRI clinical examination electromyography nerve conduction study
gptkbp:firstDescribed	gptkb:Jean-Martin_Charcot
gptkbp:hereditary	5-10% cases
https://www.w3.org/2000/01/rdf-schema#label	ALS (Lou Gehrig's disease)
gptkbp:ICD-10_code	G12.2
gptkbp:incidence	2 per 100,000 per year
gptkbp:medianSurvival	2-5 years
gptkbp:MeSH_ID	D000690
gptkbp:namedAfter	gptkb:Lou_Gehrig
gptkbp:OMIM	105400
gptkbp:onset	adult
gptkbp:prevalence	5 per 100,000
gptkbp:prognosis	poor
gptkbp:progression	progressive
gptkbp:riskFactor	age genetics male sex
gptkbp:sporadic	90-95% cases
gptkbp:studiedBy	gptkb:ALS_Association
gptkbp:symptom	paralysis cramps muscle twitching spasticity
gptkbp:treatment	gptkb:edaravone gptkb:riluzole supportive care
gptkbp:bfsParent	gptkb:Gene_Brito gptkb:Matthew_Saad_Muhammad
gptkbp:bfsLayer	7