calcitriol

URI: https://gptkb.org/entity/calcitriol

GPTKB entity

Predicate	Object
gptkbp:instanceOf	hormone vitamin D metabolite
gptkbp:ATCCode	A11CC04
gptkbp:biological_role	regulates calcium and phosphate metabolism
gptkbp:brand	gptkb:Rocaltrol gptkb:Calcijex
gptkbp:CASNumber	32222-06-3
gptkbp:chemicalFormula	C27H44O3
gptkbp:contraindication	gptkb:hypercalcemia
gptkbp:decreases_synthesis_of	gptkb:parathyroid_hormone
gptkbp:discoveredBy	1971
gptkbp:eliminationHalfLife	5-8 hours
gptkbp:FDAApproved	1998
gptkbp:foundIn	humans other vertebrates
https://www.w3.org/2000/01/rdf-schema#label	calcitriol
gptkbp:increases_absorption_of	calcium phosphate
gptkbp:IUPACName	(1R,3S,5Z,7E,22E)-9,10-secocholesta-5,7,10(19),22-tetraene-1,3,25-triol
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	activates vitamin D receptor
gptkbp:meltingPoint	120 °C
gptkbp:metabolism	liver
gptkbp:molecularWeight	416.64 g/mol
gptkbp:predecessor	gptkb:25-hydroxyvitamin_D3
gptkbp:pregnancyCategory	C (US)
gptkbp:producedBy	gptkb:kidney
gptkbp:PubChem_CID	5280453 CHEBI:17823
gptkbp:regulates	parathyroid hormone secretion
gptkbp:relatedTo	gptkb:cholecalciferol gptkb:alfacalcidol gptkb:doxercalciferol gptkb:ergocalciferol gptkb:paricalcitol
gptkbp:routeOfAdministration	oral intravenous
gptkbp:sideEffect	gptkb:hypercalcemia nausea vomiting abdominal pain constipation headache muscle pain weakness polyuria
gptkbp:UNII	FXC9231JVH
gptkbp:usedFor	gptkb:bone gptkb:secondary_hyperparathyroidism chronic kidney disease hypocalcemia
gptkbp:bfsParent	gptkb:vitamin_A
gptkbp:bfsLayer	4