Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:neurodegenerative_diseases
|
| gptkbp:associated_with |
gptkb:familial_amyloid_cardiomyopathy
gptkb:familial_amyloid_polyneuropathy gptkb:cardiac_amyloidosis aging hereditary factors |
| gptkbp:caused_by |
transthyretin protein misfolding
|
| gptkbp:clinical_trial |
gptkb:depression
anxiety dizziness fatigue nausea sleep disturbances weight loss abdominal pain dry eyes vomiting diarrhea hearing loss joint pain muscle weakness constipation dry mouth visual impairment arrhythmias shortness of breath weight gain numbness peripheral neuropathy carpal tunnel syndrome tingling sensations urinary incontinence muscle cramps skin rashes skin changes swelling in legs brittle nails gastrointestinal issues autonomic dysfunction erectile dysfunction bradycardia thinning hair joint stiffness vision changes sweating abnormalities fainting spells puffy face thickened tongue |
| gptkbp:diagnosis |
genetic testing
biopsy |
| gptkbp:first_described_by |
gptkb:1952
|
| https://www.w3.org/2000/01/rdf-schema#label |
transthyretin amyloidosis
|
| gptkbp:prevalence |
rare disease
|
| gptkbp:research_areas |
gptkb:Genetics
clinical trials pathology treatment options |
| gptkbp:risk_factor |
family history
certain ethnic groups mutations in TTR gene |
| gptkbp:symptoms |
heart failure
carpal tunnel syndrome neuropathy |
| gptkbp:treatment |
gptkb:diflunisal
gptkb:tafamidis liver transplantation |
| gptkbp:bfsParent |
gptkb:tafamidis
|
| gptkbp:bfsLayer |
7
|