|
gptkbp:instanceOf
|
benzodiazepine
sedative
general anesthetic
|
|
gptkbp:ATCCode
|
N01AF03
|
|
gptkbp:CASNumber
|
76-75-5
|
|
gptkbp:chemicalFormula
|
C11H17N2NaO2S
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
porphyria
hypersensitivity to barbiturates
|
|
gptkbp:discoveredBy
|
gptkb:Donalee_L._Tabern
gptkb:Ernest_H._Volwiler
1934
|
|
gptkbp:eliminationHalfLife
|
5-11 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:firstSynthesized
|
gptkb:Abbott_Laboratories
|
|
gptkbp:has_shelf_life
|
unstable in solution
|
|
gptkbp:hasInChIKey
|
BSYNRYMUTXBXSQ-UHFFFAOYSA-M
|
|
gptkbp:hasSMILES
|
CCC(C)C1C(=O)NC(=S)NC1=O.[Na]
|
|
gptkbp:hasUNII
|
KHS5GLS2J3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
thiopental sodium
|
|
gptkbp:IUPACName
|
sodium 5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate
|
|
gptkbp:KEGGID
|
D00541
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
gptkb:Pentothal
|
|
gptkbp:mass
|
264.32 g/mol
|
|
gptkbp:mechanismOfAction
|
GABA-A receptor agonist
|
|
gptkbp:meltingPoint
|
162 °C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:produces_effect
|
CNS depression
|
|
gptkbp:PubChem_CID
|
16641
15781
CHEMBL1200727
DB00599
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
hypotension
respiratory depression
cardiac depression
|
|
gptkbp:solubility
|
high
|
|
gptkbp:used_in
|
induction of coma
lethal injection (some jurisdictions)
|
|
gptkbp:usedFor
|
induction of anesthesia
short-term anesthesia
treatment of increased intracranial pressure
|
|
gptkbp:bfsParent
|
gptkb:sodium_pentothal
gptkb:Sodium_thiopental
|
|
gptkbp:bfsLayer
|
7
|