Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
|
| gptkbp:activities |
high in stem cells
low in somatic cells |
| gptkbp:associated_with |
gptkb:Oncology
cellular aging |
| gptkbp:clinical_use |
telomerase as a biomarker
telomerase-targeted cancer therapies telomerase reverse transcriptase (TERT) gene therapy |
| gptkbp:composed_of |
RNA and protein
|
| gptkbp:discovered_by |
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn gptkb:Jack_Szostak |
| gptkbp:discovery |
gptkb:Harvard_University
gptkb:Johns_Hopkins_University gptkb:Massachusetts_Institute_of_Technology gptkb:University_of_California,_Berkeley understanding of aging understanding of cancer biology contributed to the understanding of genetic diseases enhanced understanding of genetic stability first enzyme shown to extend telomeres influenced aging research inspired further research on telomere dynamics led to advancements in regenerative medicine led to the development of telomerase activators opened new avenues for cancer research paved the way for telomere biology studies provided insights into cellular immortality telomere hypothesis of aging telomere shortening theory highlighted the role of telomeres in chromosome protection contributed to Nobel Prize in Physiology or Medicine 2009 influenced therapeutic strategies for age-related diseases |
| gptkbp:discovery_year |
gptkb:1984
|
| gptkbp:function |
maintains telomeres
|
| https://www.w3.org/2000/01/rdf-schema#label |
telomerase
|
| gptkbp:initiated_by |
gptkb:Imetelstat
gptkb:OBP-301 gptkb:Telo-2 potential cancer treatments BIBR1532 GRN163 L |
| gptkbp:is_found_in |
eukaryotic cells
|
| gptkbp:research_areas |
gptkb:Genetics
molecular biology biogerontology |
| gptkbp:role |
extending chromosome ends
|
| gptkbp:bfsParent |
gptkb:Carol_Greider
|
| gptkbp:bfsLayer |
4
|