|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:complex_II
gptkb:succinate-coenzyme_Q_reductase
|
|
gptkbp:associatedWith
|
gptkb:mitochondrial_complex_II
|
|
gptkbp:biologicalProcess
|
oxidoreductase activity
|
|
gptkbp:catalyzes
|
oxidation of succinate to fumarate
|
|
gptkbp:cofactor
|
gptkb:FAD
iron-sulfur clusters
|
|
gptkbp:component
|
electron transport chain
citric acid cycle
|
|
gptkbp:deficiencyCauses
|
gptkb:pheochromocytoma
paraganglioma
mitochondrial disease
|
|
gptkbp:determines
|
X-ray crystallography
|
|
gptkbp:EC_number
|
1.3.5.1
|
|
gptkbp:electronAcceptor
|
ubiquinone
|
|
gptkbp:electronDonor
|
succinate
|
|
gptkbp:firstDescribed
|
1950s
|
|
gptkbp:foundIn
|
prokaryotes
eukaryotes
|
|
gptkbp:gene
|
gptkb:SDHA
gptkb:SDHB
gptkb:SDHC
gptkb:SDHD
|
|
gptkbp:GO_term
|
GO:0008177
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
succinate dehydrogenase
|
|
gptkbp:inhibitedBy
|
malonate
|
|
gptkbp:involvedIn
|
energy production
aerobic respiration
|
|
gptkbp:locatedIn
|
inner mitochondrial membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Leigh_syndrome
gptkb:hereditary_paraganglioma-pheochromocytoma_syndromes
gptkb:mitochondrial_complex_II_deficiency
|
|
gptkbp:OMIM
|
600857
|
|
gptkbp:product
|
fumarate
|
|
gptkbp:requires
|
ATP synthesis
|
|
gptkbp:substrate
|
succinate
|
|
gptkbp:subunit
|
gptkb:SDHA
gptkb:SDHB
gptkb:SDHC
gptkb:SDHD
|
|
gptkbp:UniProtID
|
gptkb:Q99643_(SDHC,_human)
O14521 (SDHD, human)
P21912 (SDHB, human)
P31040 (SDHA, human)
|
|
gptkbp:bfsParent
|
gptkb:Krebs_cycle
|
|
gptkbp:bfsLayer
|
5
|