Statements (77)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:muscular_dystrophy
dystrophin-glycoprotein complex |
| gptkbp:challenges |
leads to muscle degeneration
|
| gptkbp:discovered_by |
1990s
|
| gptkbp:form |
SGCA isoform 1
SGCA isoform 2 |
| gptkbp:function |
cell adhesion
|
| gptkbp:genetic_studies |
causes limb-girdle muscular dystrophy type 2 D
|
| gptkbp:has_role |
membrane protein
structural protein |
| https://www.w3.org/2000/01/rdf-schema#label |
sarcoglycan alpha
|
| gptkbp:interacts_with |
gptkb:sarcoglycan_beta
gptkb:sarcoglycan_delta gptkb:sarcoglycan_gamma |
| gptkbp:involved_in |
muscle development
muscle repair muscle cell signaling muscle integrity |
| gptkbp:is_essential_for |
muscle function
|
| gptkbp:is_expressed_in |
skeletal muscle
cardiac muscle adult muscle embryonic muscle |
| gptkbp:is_found_in |
cardiac muscle fibers
skeletal muscle fibers |
| gptkbp:is_involved_in |
muscle regeneration
cell communication cell signaling pathways tissue repair cell adhesion processes muscle fiber adaptation muscle fiber differentiation muscle fiber growth muscle fiber maintenance muscle fiber regeneration muscle fiber remodeling muscle fiber repair muscle fiber response to aging muscle fiber response to cytokines muscle fiber response to disease muscle fiber response to environmental stress muscle fiber response to exercise muscle fiber response to exercise training muscle fiber response to growth factors muscle fiber response to hormones muscle fiber response to inflammatory signals muscle fiber response to injury muscle fiber response to injury signals muscle fiber response to mechanical load muscle fiber response to metabolic stress muscle fiber response to nutrition muscle fiber response to oxidative stress muscle fiber response to physical activity muscle fiber response to rehabilitation muscle fiber response to stress muscle fiber stability muscle homeostasis |
| gptkbp:is_linked_to |
muscle diseases
|
| gptkbp:is_part_of |
cell membrane structure
extracellular matrix muscle cell membrane muscle cell architecture muscle contraction mechanism muscle fiber structure |
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_studied_in |
clinical trials
genetic research |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
pharmacological treatments |
| gptkbp:located_in |
muscle tissue
|
| gptkbp:part_of |
sarcolemma
|
| gptkbp:promoter |
SGCA
|
| gptkbp:related_to |
sarcoglycan family
|
| gptkbp:weight |
approximately 43 k Da
|
| gptkbp:bfsParent |
gptkb:sarcoglycan_complex
|
| gptkbp:bfsLayer |
7
|