Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
acetyl-CoA
|
| gptkbp:CASNumber |
9001-99-4
|
| gptkbp:catalyzes |
conversion of pyruvate to oxaloacetate
|
| gptkbp:cofactor |
gptkb:biotin
|
| gptkbp:deficiencyCauses |
gptkb:pyruvate_carboxylase_deficiency
|
| gptkbp:discoveredBy |
gptkb:Fritz_Lipmann
|
| gptkbp:EC_number |
6.4.1.1
|
| gptkbp:firstDescribed |
1959
|
| gptkbp:foundIn |
mitochondria
|
| gptkbp:gene |
PC
|
| gptkbp:gene_location_(human) |
gptkb:chromosome_11q13.2
|
| https://www.w3.org/2000/01/rdf-schema#label |
pyruvate carboxylase
|
| gptkbp:inhibitedBy |
gptkb:oxaloacetate
gptkb:aspartate |
| gptkbp:involves |
gluconeogenesis
anaplerotic reactions |
| gptkbp:molecularWeight |
~130 kDa (per subunit)
|
| gptkbp:presentIn |
gptkb:skeletal_muscle
gptkb:kidney brain liver adipose tissue |
| gptkbp:requires |
gptkb:ATP
CO2 |
| gptkbp:structure |
tetramer
|
| gptkbp:UniProtID |
P11498
|
| gptkbp:bfsParent |
gptkb:pyruvate
gptkb:BCCP gptkb:oxaloacetate |
| gptkbp:bfsLayer |
6
|