primary biliary cholangitis (PBC)

URI: https://gptkb.org/entity/primary_biliary_cholangitis_(PBC)
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:liver_disease
autoimmune disease
gptkbp:abbreviation gptkb:PBC
gptkbp:affects liver
gptkbp:associatedWith gptkb:antimitochondrial_antibodies_(AMA)
fatigue
jaundice
pruritus
xanthomas
hyperlipidemia
elevated alkaline phosphatase
gptkbp:cause cirrhosis
liver failure
cholestasis
gptkbp:characterizedBy progressive destruction of intrahepatic bile ducts
gptkbp:commonIn gptkb:women
gptkbp:complication gptkb:bone
hepatocellular carcinoma
portal hypertension
gptkbp:diagnosedBy imaging
serology
liver biopsy
gptkbp:firstDescribed 1851
gptkbp:formerName gptkb:primary_biliary_cirrhosis
https://www.w3.org/2000/01/rdf-schema#label primary biliary cholangitis (PBC)
gptkbp:ICD-10_code K74.3
gptkbp:prevalence 1 in 1,000 women over age 40
gptkbp:riskFactor family history
other autoimmune diseases
gptkbp:treatment gptkb:obeticholic_acid
gptkb:ursodeoxycholic_acid
liver transplantation
gptkbp:typicalOnsetAge 30-60 years
gptkbp:bfsParent gptkb:Intercept_Pharmaceuticals
gptkbp:bfsLayer 7