Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:psychologist
cognitive decline neuroinflammation neurodegenerative disorders neurodegeneration tau pathology cognitive dysfunction memory impairment synaptic loss |
| gptkbp:clinical_trial |
studied for therapeutic targets
linked to familial Alzheimer's disease investigated for drug development potential biomarker for Alzheimer's disease |
| gptkbp:composed_of |
heterodimer with presenilin-1
|
| gptkbp:discovered_by |
gptkb:1996
|
| gptkbp:ecological_role |
regulation of apoptosis
contributes to amyloid plaque formation |
| gptkbp:established |
gamma-secretase inhibitors
|
| gptkbp:function |
involved in the processing of amyloid precursor protein
involved in proteolytic processing modulates amyloid-beta production regulates calcium homeostasis |
| gptkbp:genetic_diversity |
highly conserved across species
missense mutations increased risk of Alzheimer's disease |
| gptkbp:habitat |
gptkb:chromosome_1
|
| https://www.w3.org/2000/01/rdf-schema#label |
presenilin-2 protein
|
| gptkbp:intelligence |
found in various species
|
| gptkbp:interacts_with |
gamma-secretase
with other proteins in the gamma-secretase complex |
| gptkbp:is_a_route_for |
cell signaling
|
| gptkbp:is_involved_in |
Notch signaling pathway
intracellular signaling |
| gptkbp:is_represented_in |
gptkb:microprocessor
highly expressed in the brain |
| gptkbp:is_studied_in |
therapeutic interventions
animal models of Alzheimer's disease |
| gptkbp:is_tested_for |
genetic testing for mutations
|
| gptkbp:location |
plasma membrane
endoplasmic reticulum |
| gptkbp:nutritional_value |
crystal structure determined
presenilin family |
| gptkbp:partnership |
APP (amyloid precursor protein)
|
| gptkbp:promoter |
PSE N2
|
| gptkbp:regulatory_compliance |
regulated by transcription factors
|
| gptkbp:related_to |
presenilin-1 protein
|
| gptkbp:research |
gene knockout studies
linked to synaptic dysfunction |
| gptkbp:research_areas |
neurobiology
|
| gptkbp:research_focus |
Alzheimer's disease mechanisms
understanding Alzheimer's pathogenesis |
| gptkbp:role |
important for neural development
involved in neurotoxic effects |
| gptkbp:social_responsibility |
mutations can lead to early-onset Alzheimer's disease
|
| gptkbp:social_structure |
contains multiple transmembrane domains
|
| gptkbp:type |
transmembrane protein
|
| gptkbp:weight |
approximately 50 k Da
|