|
gptkbp:instanceOf
|
anthelmintic drug
|
|
gptkbp:approvalYear
|
1978
|
|
gptkbp:approvedBy
|
gptkb:Germany
gptkb:FDA
|
|
gptkbp:ATCCode
|
P02BA01
|
|
gptkbp:bioavailability
|
~80%
|
|
gptkbp:brand
|
gptkb:Biltricide
gptkb:Cesol
gptkb:Distocide
|
|
gptkbp:CASNumber
|
55268-74-1
|
|
gptkbp:chemicalFormula
|
C19H24N2O2
|
|
gptkbp:contraindication
|
ocular cysticercosis
|
|
gptkbp:cost
|
low
|
|
gptkbp:discoveredBy
|
gptkb:Merck_KGaA
|
|
gptkbp:discoveredIn
|
1972
|
|
gptkbp:eliminationHalfLife
|
0.8–1.5 hours
|
|
gptkbp:essentialMedicine
|
yes
|
|
gptkbp:excretion
|
urine
bile
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
praziquantel
|
|
gptkbp:KEGGID
|
D00456
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
increases permeability of cell membranes to calcium ions
|
|
gptkbp:MedlinePlusID
|
a608036
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
312.41 g/mol
|
|
gptkbp:pregnancyCategory
|
B (US)
B1 (Australia)
|
|
gptkbp:PubChem_CID
|
4891
CHEMBL1409
DB01058
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
dizziness
headache
|
|
gptkbp:synonym
|
gptkb:PZQ
gptkb:Praziquantelum
|
|
gptkbp:UNII
|
6T4T6UM51A
|
|
gptkbp:usedFor
|
treatment of neurocysticercosis
treatment of clonorchiasis
treatment of diphyllobothriasis
treatment of liver fluke infections
treatment of opisthorchiasis
treatment of paragonimiasis
treatment of schistosomiasis
treatment of taeniasis
treatment of tapeworm infections
|
|
gptkbp:usedInVeterinaryMedicine
|
yes
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Schistosoma
gptkb:Taenia_solium
gptkb:blood_fluke
gptkb:Taenia
gptkb:liver_fluke
gptkb:tapeworm
gptkb:Bayer_Quad_Dewormer_(pet_product)
gptkb:Bayer_Tapeworm_Dewormer_(pet_product)
|
|
gptkbp:bfsLayer
|
6
|