podophyllotoxin

URI: https://gptkb.org/entity/podophyllotoxin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:natural_product gptkb:lignan
gptkbp:ATCCode	D06BB04
gptkbp:CASNumber	518-28-5
gptkbp:category	gptkb:metabolite gptkb:plant_toxin gptkb:antimitotic_agent
gptkbp:chemicalFormula	C22H22O8
gptkbp:discoveredBy	Georg Dragendorff
gptkbp:discoveredIn	1880
gptkbp:foundIn	gptkb:Podophyllum_hexandrum gptkb:Podophyllum_peltatum Dysosma versipellis
gptkbp:IUPACName	(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-5,9-dihydroxy-2,5a,8,8a-tetramethyldibenzo[a,c]cycloocten-6-one
gptkbp:mechanismOfAction	inhibits microtubule assembly
gptkbp:meltingPoint	183–185 °C
gptkbp:molecularWeight	414.41 g/mol
gptkbp:PubChem_CID	gptkb:CHEMBL418 10607 CHEBI:8053 DB01179
gptkbp:relatedTo	gptkb:antineoplastic_agent teniposide
gptkbp:solubility	insoluble in water soluble in alcohol
gptkbp:toxicity	toxic if ingested
gptkbp:UNII	X6XEA46401
gptkbp:used_in_medicine	treatment of external genital warts
gptkbp:usedFor	precursor for anticancer drugs topical treatment for genital warts
gptkbp:bfsParent	gptkb:Podophyllum_hexandrum gptkb:VP-16 gptkb:picropodophyllin
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	podophyllotoxin