phosphatidylinositol 3-kinase
GPTKB entity
Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
|
| gptkbp:activator |
growth factors
|
| gptkbp:associated_with |
gptkb:Oncology
metabolic disorders |
| gptkbp:clinical_trial |
biomarker for cancer
target for cancer therapy involved in drug resistance associated with diabetes associated with obesity |
| gptkbp:family |
phosphoinositide 3-kinases
|
| gptkbp:function |
phosphorylates inositol lipids
|
| gptkbp:fuselage_material |
phosphatidylinositol 4,5-bisphosphate
|
| https://www.w3.org/2000/01/rdf-schema#label |
phosphatidylinositol 3-kinase
|
| gptkbp:initiated_by |
gptkb:Copanlisib
gptkb:Duvelisib gptkb:Idelalisib Alpelisib PI3 K inhibitors |
| gptkbp:involved_in |
cell signaling
|
| gptkbp:location |
cytoplasm
|
| gptkbp:pathway |
apoptosis regulation
cell cycle regulation insulin signaling pathway AKT signaling pathway m TOR signaling pathway |
| gptkbp:produces |
phosphatidylinositol 3,4,5-trisphosphate
|
| gptkbp:promoter |
gptkb:PIK3_CA
PIK3 CB PIK3 CD PIK3 CG |
| gptkbp:research |
target for drug development
role in inflammation role in aging role in autoimmune diseases role in bone health role in cardiovascular diseases role in eye health role in fat metabolism role in hearing role in kidney function role in liver function role in lung function role in muscle growth role in neurodegenerative diseases role in reproductive health role in skin health role in smell perception role in stem cell biology role in taste perception role in tissue regeneration role in wound healing |
| gptkbp:role |
regulating metabolism
regulating cell growth regulating cell survival |
| gptkbp:type |
class I PI3 K
class II PI3 K class III PI3 K |
| gptkbp:bfsParent |
gptkb:PIK3_CA
|
| gptkbp:bfsLayer |
6
|