Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
amino acid derivative chelating agent |
| gptkbp:ATCCode |
M01CC01
|
| gptkbp:CASNumber |
52-67-5
|
| gptkbp:category |
gptkb:WHO_essential_medicines
organosulfur compound amino acid transporter antidote chelator antirheumatic agent thiol compound |
| gptkbp:chemicalFormula |
C5H11NO2S
|
| gptkbp:contraindication |
pregnancy
renal impairment |
| gptkbp:derivedFrom |
gptkb:antibiotic
|
| gptkbp:discoveredBy |
John Walshe
|
| gptkbp:discoveredIn |
1956
|
| gptkbp:eliminationHalfLife |
1-7 hours
|
| gptkbp:excretion |
urine
|
| https://www.w3.org/2000/01/rdf-schema#label |
penicillamine
|
| gptkbp:IUPACName |
(2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
|
| gptkbp:KEGGID |
D08367
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
reduces cystine stone formation
immunomodulatory effects chelates heavy metals |
| gptkbp:meltingPoint |
212–215 °C
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
149.21 g/mol
|
| gptkbp:pregnancyCategory |
D (US)
|
| gptkbp:PubChem_CID |
4676
CHEMBL1425 CHEBI:7943 DB00859 |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
aplastic anemia
autoimmune disorders proteinuria rash leukopenia |
| gptkbp:synonym |
3-mercapto-D-valine
D-penicillamine beta,beta-dimethylcysteine |
| gptkbp:UNII |
9H3C539U1D
|
| gptkbp:usedFor |
gptkb:Wilson's_disease
rheumatoid arthritis cystinuria |
| gptkbp:bfsParent |
gptkb:Cuprimine
|
| gptkbp:bfsLayer |
7
|