|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:administered_by
|
subcutaneous injection
|
|
gptkbp:approves
|
gptkb:2002
gptkb:FDA
|
|
gptkbp:atccode
|
L03 AA13
|
|
gptkbp:availability
|
prescription only
|
|
gptkbp:bioavailability
|
not applicable
|
|
gptkbp:chemical_formula
|
C_22 H_28 N_4 O_5 S
|
|
gptkbp:class
|
biologic
granulocyte colony-stimulating factor
|
|
gptkbp:clinical_trial
|
Phase III
|
|
gptkbp:clinical_use
|
preventing febrile neutropenia
|
|
gptkbp:contraindication
|
gptkb:sickle_cell_disease
hypersensitivity to pegfilgrastim
|
|
gptkbp:developed_by
|
gptkb:Amgen
|
|
gptkbp:dosage_form
|
6 mg once per chemotherapy cycle
|
|
gptkbp:drug_interactions
|
none significant
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:financial_stability
|
stable for 48 hours at room temperature
|
|
gptkbp:formulation
|
solution for injection
|
|
gptkbp:healthcare
|
2002-04-01
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pegfilgrastim
|
|
gptkbp:incompatibilities
|
do not mix with other medications
|
|
gptkbp:indication
|
chemotherapy-induced neutropenia
|
|
gptkbp:ingredients
|
gptkb:pegfilgrastim
|
|
gptkbp:invention
|
patented
|
|
gptkbp:lifespan
|
15 to 80 hours
|
|
gptkbp:manufacturer
|
gptkb:Amgen_Inc.
|
|
gptkbp:marketed_as
|
gptkb:Neulasta
|
|
gptkbp:mechanism_of_action
|
stimulates bone marrow to produce neutrophils
|
|
gptkbp:metabolism
|
primarily in the liver
|
|
gptkbp:packaging
|
single-use prefilled syringe
|
|
gptkbp:patient_education
|
instruct on injection technique
|
|
gptkbp:patient_population
|
cancer patients
|
|
gptkbp:pharmacokinetics
|
linear pharmacokinetics
increases neutrophil count
|
|
gptkbp:previous_name
|
gptkb:pegfilgrastim
|
|
gptkbp:price
|
varies by region
|
|
gptkbp:provides_guidance_on
|
recommended in NCCN guidelines
|
|
gptkbp:requires
|
available on FDA website
|
|
gptkbp:route_of_administration
|
subcutaneous
|
|
gptkbp:safety_measures
|
monitor for allergic reactions
|
|
gptkbp:side_effect
|
fatigue
headache
nausea
fever
acute respiratory distress syndrome
bone pain
thrombocytopenia
leukocytosis
splenic rupture
|
|
gptkbp:storage
|
store in refrigerator
|
|
gptkbp:trade
|
gptkb:Neulasta
|
|
gptkbp:used_for
|
reducing the risk of infection
|
|
gptkbp:bfsParent
|
gptkb:Neulasta
|
|
gptkbp:bfsLayer
|
5
|