Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:administered_by |
adults and children
exercise programs subcutaneous injection dietary modifications patients with congenital leptin deficiency patients with generalized lipodystrophy |
| gptkbp:affects |
energy balance
appetite regulation |
| gptkbp:approves |
gptkb:FDA
|
| gptkbp:composed_by |
recombinant DNA technology
|
| gptkbp:contraindication |
pregnant women
nursing mothers |
| gptkbp:developed_by |
gptkb:Amgen
|
| https://www.w3.org/2000/01/rdf-schema#label |
metreleptin
|
| gptkbp:investigates |
potential use in cardiovascular diseases
potential use in diabetes potential use in metabolic syndrome |
| gptkbp:is_administered_once |
daily
|
| gptkbp:is_available_in |
vial form
|
| gptkbp:is_considered |
a therapeutic agent
a recombinant protein |
| gptkbp:is_effective_against |
non-leptin deficient obesity
|
| gptkbp:is_evaluated_by |
long-term efficacy
long-term safety |
| gptkbp:is_monitored_by |
effectiveness
adverse effects |
| gptkbp:is_not_approved_for |
weight loss in non-deficient individuals
|
| gptkbp:is_part_of |
leptin signaling pathway
hormonal therapy treatment for metabolic disorders endocrine therapy treatment regimen for lipodystrophy |
| gptkbp:is_related_to |
insulin sensitivity
fat metabolism glucose homeostasis |
| gptkbp:is_similar_to |
human leptin
|
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_used_in |
clinical practice
human studies animal studies research on obesity research on metabolic disorders |
| gptkbp:related_to |
metabolic syndrome
obesity |
| gptkbp:side_effect |
fatigue
headache nausea injection site reactions hypoglycemia |
| gptkbp:suitable_for |
patients without leptin deficiency
|
| gptkbp:used_for |
treatment of leptin deficiency
|
| gptkbp:weight |
approximately 16 k Da
|
| gptkbp:bfsParent |
gptkb:Myalept
|
| gptkbp:bfsLayer |
6
|