Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Oncology
|
| gptkbp:associated_with |
gptkb:pheochromocytoma
hyperparathyroidism MEN 2 syndrome RET proto-oncogene mutations |
| gptkbp:can_be_familial |
gptkb:true
|
| gptkbp:can_be_used_to |
fatigue
nausea weight loss abdominal pain diarrhea flushing |
| gptkbp:can_detect |
genetic testing
imaging tests |
| gptkbp:can_lead_to |
hypercalcemia
thyroid dysfunction hypocalcemia |
| gptkbp:can_metastasize_to |
liver
lungs lymph nodes |
| gptkbp:cause |
calcitonin secretion
|
| gptkbp:descendant |
gptkb:true
|
| gptkbp:diagnosis |
immunohistochemistry
fine needle aspiration biopsy serum calcitonin levels variable based on stage |
| gptkbp:first_described_by |
1970s
|
| gptkbp:follow_up_care_includes |
imaging studies
regular monitoring of calcitonin levels |
| https://www.w3.org/2000/01/rdf-schema#label |
medullary thyroid cancer
|
| gptkbp:is_characterized_by |
C-cell hyperplasia
calcitonin-producing tumors neuroendocrine differentiation |
| gptkbp:is_common_in |
gptkb:women
gptkb:children adults men |
| gptkbp:is_considered |
aggressive form of thyroid cancer
|
| gptkbp:is_effective_against |
anaplastic thyroid cancer
|
| gptkbp:is_linked_to |
RET gene mutations
|
| gptkbp:is_more_aggressive_than |
gptkb:papillary_thyroid_cancer
|
| gptkbp:is_often_associated_with |
other cancers
|
| gptkbp:is_part_of |
thyroid cancer spectrum
|
| gptkbp:may_require_follow_up |
lifelong monitoring
|
| gptkbp:occurs_in |
other endocrine tumors
0.5% of all thyroid cancers |
| gptkbp:originated_in |
C cells of the thyroid
|
| gptkbp:prevalence |
rare
|
| gptkbp:requires |
lymph node dissection
thyroidectomy |
| gptkbp:risk_factor |
family history
genetic mutations |
| gptkbp:screenings |
high-risk individuals
|
| gptkbp:symptoms |
difficulty swallowing
hoarseness neck mass |
| gptkbp:treatment |
gptkb:surgery
radiation therapy chemotherapy targeted therapy multidisciplinary approach hormonal therapy |
| gptkbp:bfsParent |
gptkb:Pralsetinib
|
| gptkbp:bfsLayer |
5
|