Statements (20)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:antimitotic_agent
gptkb:chemical_compound |
| gptkbp:CASNumber |
35846-53-8
|
| gptkbp:chemicalFormula |
C62H86O18N2S
|
| gptkbp:clinical_use |
not used as a single agent due to toxicity
|
| gptkbp:mechanismOfAction |
inhibits microtubule assembly
|
| gptkbp:molecularWeight |
1083.4 g/mol
|
| gptkbp:notableDerivative |
gptkb:DM1
DM4 |
| gptkbp:origin |
isolated from Maytenus ovatus
|
| gptkbp:structure |
ansamycin-type macrolide
|
| gptkbp:target |
tubulin
|
| gptkbp:toxicity |
highly cytotoxic
|
| gptkbp:used_in |
mirvetuximab soravtansine
trastuzumab emtansine (T-DM1) |
| gptkbp:uses |
gptkb:antineoplastic_agent
used in antibody-drug conjugates |
| gptkbp:bfsParent |
gptkb:DM1_(emtansine)
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
maytansine
|