maytansine

GPTKB entity

Statements (20)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antimitotic agent
gptkbp:CASNumber 35846-53-8
gptkbp:chemicalFormula C62H86O18N2S
gptkbp:clinical_use not used as a single agent due to toxicity
https://www.w3.org/2000/01/rdf-schema#label maytansine
gptkbp:mechanismOfAction inhibits microtubule assembly
gptkbp:molecularWeight 1083.4 g/mol
gptkbp:notableDerivative gptkb:DM1
DM4
gptkbp:origin isolated from Maytenus ovatus
gptkbp:structure ansamycin-type macrolide
gptkbp:target tubulin
gptkbp:toxicity highly cytotoxic
gptkbp:used_in mirvetuximab soravtansine
trastuzumab emtansine (T-DM1)
gptkbp:uses antineoplastic agent
used in antibody-drug conjugates
gptkbp:bfsParent gptkb:DM1_(emtansine)
gptkbp:bfsLayer 7