|
gptkbp:instanceOf
|
gptkb:drug
immunosuppressant
|
|
gptkbp:approvedBy
|
1998
|
|
gptkbp:ATCCode
|
gptkb:L04AA13
|
|
gptkbp:bioavailability
|
80-90%
|
|
gptkbp:CASNumber
|
75706-12-6
|
|
gptkbp:chemicalFormula
|
C12H9F3N2O2
|
|
gptkbp:contraindication
|
pregnancy
severe liver impairment
|
|
gptkbp:developedBy
|
gptkb:Sanofi
|
|
gptkbp:eliminationHalfLife
|
2 weeks
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:genericName
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
leflunomide
|
|
gptkbp:KEGGID
|
D00748
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
dihydroorotate dehydrogenase inhibitor
|
|
gptkbp:metabolism
|
gptkb:teriflunomide
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:pregnancyWarning
|
teratogenic
|
|
gptkbp:proteinBinding
|
>99%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1092
3899
DB01097
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
diarrhea
hypertension
rash
liver toxicity
|
|
gptkbp:synonym
|
gptkb:Arava
HWA 486
|
|
gptkbp:UNII
|
7GR28W0FJI
|
|
gptkbp:usedFor
|
gptkb:psoriatic_arthritis
rheumatoid arthritis
|
|
gptkbp:bfsParent
|
gptkb:Arava
|
|
gptkbp:bfsLayer
|
6
|