Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
epilepsy syndrome
|
| gptkbp:affects |
adolescents
young adults |
| gptkbp:alsoKnownAs |
gptkb:JME
Janz syndrome |
| gptkbp:associatedWith |
GABRA1
CACNB4 CLCN2 EFHC1 |
| gptkbp:category |
idiopathic generalized epilepsy
|
| gptkbp:diagnosedBy |
gptkb:EEG
|
| gptkbp:EEGPattern |
generalized 4-6 Hz polyspike and wave discharges
|
| gptkbp:firstDescribed |
Hermann Janz
|
| gptkbp:frequency |
daily myoclonic jerks
|
| gptkbp:gender |
equal male and female prevalence
|
| gptkbp:geneticStudies |
yes
|
| https://www.w3.org/2000/01/rdf-schema#label |
juvenile myoclonic epilepsy
|
| gptkbp:ICD-10_code |
G40.3
|
| gptkbp:inheritance |
complex, polygenic
|
| gptkbp:lifestyleAdvice |
avoid alcohol
avoid sleep deprivation |
| gptkbp:longTermManagement |
antiepileptic drugs
|
| gptkbp:MeSH_ID |
D020274
|
| gptkbp:MRI_findings |
usually normal
|
| gptkbp:notRecommendedTreatment |
gptkb:phenytoin
gptkb:carbamazepine |
| gptkbp:OMIM |
254770
|
| gptkbp:onset |
adolescence
|
| gptkbp:prevalence |
5-10% of all epilepsies
most common generalized epilepsy syndrome in adolescents |
| gptkbp:prognosis |
good seizure control with medication
lifelong tendency to seizures |
| gptkbp:remissionPossible |
rarely
|
| gptkbp:riskFactor |
family history of epilepsy
|
| gptkbp:seizureDuration |
seconds (myoclonic), minutes (tonic-clonic)
|
| gptkbp:seizureTiming |
often after awakening
|
| gptkbp:seizureType |
absence
myoclonic tonic-clonic |
| gptkbp:symptom |
absence seizures
generalized tonic-clonic seizures myoclonic jerks |
| gptkbp:treatment |
gptkb:valproic_acid
gptkb:lamotrigine gptkb:levetiracetam gptkb:topiramate |
| gptkbp:triggeredBy |
alcohol consumption
stress sleep deprivation |
| gptkbp:typicalOnsetAge |
12-18 years
|
| gptkbp:bfsParent |
gptkb:GABRA1_gene
|
| gptkbp:bfsLayer |
7
|