Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:monoclonal_antibody
|
| gptkbp:abbreviation |
gptkb:IgA
|
| gptkbp:contains |
secretory component
J chain |
| gptkbp:deficiencyCauses |
increased susceptibility to infections
|
| gptkbp:discoveredBy |
David S. Rowe
|
| gptkbp:discoveredIn |
1953
|
| gptkbp:encodedBy |
IGH@ gene
|
| gptkbp:foundIn |
gastrointestinal tract
mucous membranes breast milk tears saliva respiratory tract urogenital tract |
| gptkbp:function |
immune defense at mucosal surfaces
|
| https://www.w3.org/2000/01/rdf-schema#label |
immunoglobulin A
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_14
|
| gptkbp:molecularWeight |
160 kDa
|
| gptkbp:percentageOfTotalImmunoglobulin |
10-15%
|
| gptkbp:presentIn |
humans
mammals |
| gptkbp:producedBy |
plasma cells
|
| gptkbp:significance |
gptkb:IgA_nephropathy
celiac disease selective IgA deficiency |
| gptkbp:structure |
dimer
monomer |
| gptkbp:subclassOf |
immune response
|
| gptkbp:subspecies |
IgA1
IgA2 |
| gptkbp:bfsParent |
gptkb:immunoglobulin_heavy_constant_alpha_3_protein
|
| gptkbp:bfsLayer |
7
|