Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
immune response
|
| gptkbp:antigenBindingSites |
2 (monomer)
4 (dimer) |
| gptkbp:component |
secretory immune system
|
| gptkbp:deficiencyAssociatedWith |
autoimmune diseases
recurrent infections |
| gptkbp:discoveredBy |
E. A. Kabat
|
| gptkbp:discoveredIn |
1953
|
| gptkbp:foundIn |
gastrointestinal tract
mucous membranes breast milk tears saliva respiratory tract urogenital tract |
| gptkbp:fullName |
Immunoglobulin A
|
| gptkbp:function |
immune defense
neutralization of pathogens |
| gptkbp:gene |
IGH@ (immunoglobulin heavy locus)
|
| https://www.w3.org/2000/01/rdf-schema#label |
IgA
|
| gptkbp:measures |
serum
secretions |
| gptkbp:molecularWeight |
160 kDa (monomer)
385 kDa (dimer) |
| gptkbp:percentageOfTotalImmunoglobulin |
10-15%
|
| gptkbp:presentIn |
gptkb:milk
urine bile serum cerebrospinal fluid tears saliva sweat synovial fluid colostrum amniotic fluid intestinal secretions bronchial secretions prostatic fluid |
| gptkbp:producedBy |
plasma cells
|
| gptkbp:significance |
gptkb:IgA_nephropathy
celiac disease Henoch-Schönlein purpura selective IgA deficiency |
| gptkbp:structure |
dimer
monomer |
| gptkbp:subclassOf |
IgA1
IgA2 |
| gptkbp:bfsParent |
gptkb:FcαR
gptkb:Antikörper gptkb:EA-IgA_antibody gptkb:VCA-IgA_antibody |
| gptkbp:bfsLayer |
7
|