hypoxanthine-guanine phosphoribosyltransferase (HPRT)
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
HPRT
guanine phosphoribosyltransferase hypoxanthine phosphoribosyltransferase |
| gptkbp:catalyzes |
conversion of guanine to guanosine monophosphate (GMP)
conversion of hypoxanthine to inosine monophosphate (IMP) |
| gptkbp:deficiencyCauses |
gptkb:Lesch-Nyhan_syndrome
hyperuricemia |
| gptkbp:EC_number |
2.4.2.8
|
| gptkbp:encodedBy |
gptkb:HPRT1_gene
|
| gptkbp:foundIn |
humans
mammals |
| gptkbp:function |
purine salvage pathway
|
| gptkbp:gene |
HPRT1
|
| gptkbp:HGNC_ID |
5157
|
| https://www.w3.org/2000/01/rdf-schema#label |
hypoxanthine-guanine phosphoribosyltransferase (HPRT)
|
| gptkbp:locatedOnChromosome |
Xq26.1
|
| gptkbp:molecularWeight |
~25 kDa
|
| gptkbp:OMIM |
308000
|
| gptkbp:PDB |
1HMP
|
| gptkbp:product |
guanosine monophosphate (GMP)
inosine monophosphate (IMP) |
| gptkbp:structure |
monomer or dimer
|
| gptkbp:substrate |
gptkb:hypoxanthine
guanine phosphoribosyl pyrophosphate (PRPP) |
| gptkbp:UniProtID |
P00492
|
| gptkbp:bfsParent |
gptkb:Nyhan_syndrome
|
| gptkbp:bfsLayer |
7
|