Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
bone tumor |
| gptkbp:age |
young adults
|
| gptkbp:associatedWith |
H3F3A mutation
|
| gptkbp:canBeMalignant |
rarely malignant
|
| gptkbp:complication |
lung metastasis
pathological fracture |
| gptkbp:differentialDiagnosis |
chondroblastoma
aneurysmal bone cyst brown tumor of hyperparathyroidism giant cell reparative granuloma |
| gptkbp:firstDescribed |
J. L. Simon, 1818
|
| gptkbp:frequency |
20% of benign bone tumors
5% of primary bone tumors |
| gptkbp:hasOrphanetID |
ORPHA:318
|
| gptkbp:hasPreferredImaging |
gptkb:X-rays
gptkb:CT_scan MRI |
| gptkbp:hasRadiographicFeature |
eccentric location
lytic lesion non-sclerotic margin |
| gptkbp:hasRecurrence |
local recurrence common
|
| gptkbp:hasSexPrevalence |
slightly more common in females
|
| gptkbp:hasType |
multinucleated giant cells
mononuclear stromal cells |
| gptkbp:histology |
background of mononuclear cells
numerous giant cells uniformly distributed |
| https://www.w3.org/2000/01/rdf-schema#label |
giant cell tumor of bone
|
| gptkbp:ICD-10_code |
C41.9
D48.0 |
| gptkbp:location |
epiphysis of long bones
distal femur proximal tibia distal radius |
| gptkbp:MeSH_ID |
D018225
|
| gptkbp:prognosis |
generally good with treatment
|
| gptkbp:recurrence |
high
|
| gptkbp:riskFactor |
gptkb:Paget's_disease_of_bone
|
| gptkbp:stageName |
Campanacci grading
|
| gptkbp:symptom |
pain
swelling limited joint movement |
| gptkbp:synonym |
osteoclastoma
|
| gptkbp:treatment |
gptkb:denosumab
radiation therapy bone grafting resection surgical curettage |
| gptkbp:bfsParent |
gptkb:denosumab
|
| gptkbp:bfsLayer |
8
|