gadolinium-based contrast agents

URI: https://gptkb.org/entity/gadolinium-based_contrast_agents

GPTKB entity

Statements (51)

Predicate	Object
gptkbp:instanceOf	gptkb:contrast_agent
gptkbp:alternativeTo	iodinated contrast agents
gptkbp:approvedBy	gptkb:FDA 1988
gptkbp:chemicalFormula	chelated gadolinium ion
gptkbp:compatibleWith	CT scans
gptkbp:containsElement	gptkb:gadolinium
gptkbp:contraindication	severe renal impairment
gptkbp:discoveredBy	MRI researchers
gptkbp:eliminatedIn	renal
gptkbp:example	gptkb:gadobenate_dimeglumine gptkb:gadobutrol gptkb:gadodiamide gptkb:gadopentetate_dimeglumine gptkb:gadoterate_meglumine gptkb:gadoteridol gptkb:gadoversetamide
gptkbp:excretion	urine
gptkbp:form	solution for injection
gptkbp:halfLife	1.5 hours (in normal renal function)
gptkbp:improves	T1-weighted MRI images
gptkbp:marketedAs	multiple pharmaceutical companies
gptkbp:mechanismOfAction	alters magnetic properties of nearby water molecules
gptkbp:monitoringRecommended	patients with kidney disease
gptkbp:monitors	renal function
gptkbp:notRecommendedFor	patients with acute kidney injury pregnant women (unless essential)
gptkbp:regulates	prescription only
gptkbp:regulatoryWarning	FDA warning on gadolinium retention
gptkbp:riskFactor	gptkb:nephrogenic_systemic_fibrosis gadolinium retention
gptkbp:routeOfAdministration	intravenous
gptkbp:safetyProfile	generally safe in normal renal function
gptkbp:sideEffect	nausea headache injection site reaction allergic reaction
gptkbp:storage	room temperature
gptkbp:type	linear macrocyclic
gptkbp:usedFor	enhancing MRI images
gptkbp:usedIn	magnetic resonance imaging cardiac imaging abdominal imaging musculoskeletal imaging vascular imaging CNS imaging breast MRI
gptkbp:bfsParent	gptkb:magnetic_resonance_angiography_(MRA)
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	gadolinium-based contrast agents